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- Claude Bernard -

“The joy of discovery is certainly the liveliest that the mind of man can ever feel”

Publications

Rare variant enriched identity-by-descent enables the detection of distant relatedness and older divergence between populations

May 07, 2020

Amol C. Shetty, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Population Genetics Working Group, Jeffrey O’Connell, Braxton D. Mitchell, Timothy D. O’Connor

Tobacco Hornworm (Manduca sexta) caterpillars as a novel host model for the study of fungal virulence and drug efficacy

April 30, 2020

Naomi Lyons, Isabel Softley, Andrew Balfour, Carolyn Williamson, Heath E. O’Brien, Amol C. Shetty, Vincent M. Bruno, Stephanie Diezmann

Evolutionary History of Modern Samoans

April 28, 2020

Harris DN, Kessler MD, Shetty AC, Weeks DE, Minster RL, Browning S, Cochrane EE, Deka R, Hawley NL, Reupena MS, Naseri T; Trans-Omics for Precision Medicine (TOPMed) Consortium; TOPMed Population Genetics Working Group, McGarvey ST, O'Connor TD.

Detecting Geospatial Patterns of Plasmodium Falciparum Parasite Migration in Cambodia Using Optimized Estimated Effective Migration Surfaces

April 10, 2020

Li Y, Shetty AC, Lon C, Spring M, Saunders DL, Fukuda MM, Hien TT, Pukrittayakamee S, Fairhurst RM, Dondorp AM, Plowe CV, O'Connor TD, Takala-Harrison S, Stewart K.

Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment.

March 20, 2020

Chan JC, Morgan CP, Adrian Leu N, Shetty A, Cisse YM, Nugent BM, Morrison KE, Jašarević E, Huang W, Kanyuch N, Rodgers AB, Bhanu NV, Berger DS, Garcia BA, Ament S, Kane M, Neill Epperson C, Bale TL.

De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population.

February 04, 2020

NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium

Tornadic shear stress induces a transient, calcineurin-dependent hyper-virulent phenotype in Mucorales molds

February 15, 2020

Sebastian Wurster, Alexander M. Tatara, Nathaniel D. Albert, Ashraf S. Ibrahim, Joseph Heitman, Soo Chan Lee, Amol C. Shetty, Carrie McCracken, Karen T. Graf, Antonios G. Mikos, Vincent M. Bruno, Dimitrios P. Kontoyiannis

Cost effective, experimentally robust differential expression analysis for human/mammalian, pathogen, and dual-species transcriptomics.

January 01, 2020

Shetty AC, Mattick J, Chung M, McCracken C, Mahurkar A, Filler S, Fraser CM, Rasko DA, Bruno VM, Dunning-Hotopp JC

Candida albicans quorum-sensing molecule farnesol modulates staphyloxanthin production and activates the thiol-based oxidative-stress response in Staphylococcus aureus.

July 06, 2019

Vila T, Kong EF, Ibrahim A, Piepenbrink K, Shetty AC, McCracken C, Bruno V, Jabra-Rizk MA

Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma.

December 01, 2019

NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium

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