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AMOL CARL SHETTY, PhD

I have a diverse work experience in the fields of human genomics, bioinformatics and data science. I started my career as a Bioinformatics Analyst / Developer at Emory University in 2008, where I gained experience in next-generation sequencing (NGS) and its applications in several neurodevelopment disorders namely schizophrenia, autism, and fragile X syndrome. My interest in computational biology led me to University of Maryland (UMB) in 2010 to work at the Institute for Genome Sciences (IGS), where I developed analytical methods, and high-throughput, modular, and scalable automated pipelines for transcriptomics and epigenomics. Over 18 years, as a Sr. Principal Bioinformatics Scientist at UMB, I have contributed to many oncology, organ transplant, immunology, substance abuse, clinical research, and infectious disease projects. I completed my formal education with a Doctor of Philosophy (PhD) degree in Human Genetics and Epidemiology at UMB, in 2019, while working as a full-time Bioinformatics Engineer @IGS. Prior to that, I obtained a Master's Degree in Bioinformatics from Georgia Institute of Technology (Georgia Tech), in 2007, and a Bachelor’s Degree in Biomedical Engineering from Mumbai University, in 2006. Additionally, I have obtained certifications in Management of Technology from Scheller College of Business @Georgia Tech, Statistical Methods for Functional Genomics from Cold Spring Harbor Laboratory (CSHL), AWS Machine Engineering Nanodegree from Udacity, and Emerging Leader Program @UMB. Over the past 18 years, my expertise has contributed to 250+ projects, 120+ seminal publications, 50+ scientific conferences, and several consortiums such as the NCI-funded Radiation Oncology-Biology Integration Network (ROBIN), the International Liver Transplantation Society (ILTS), the NHLBI-funded Trans-Omics for Precision Medicine (TOPMed) Program, the 3q29 Foundation, the Cure Huntington's Disease Initiative (CHDI), the NIAID-funded Genomics Based Investigation of the Determinants of Polymicrobial Infectious Disease Outcomes (GCID) Program, and the NIH-funded Neuroscience Multi-Omic (NeMO) Data Analysis Initiative. I also serve as an Associate Editor for the Computational Science Editorial Panel @Transplantation Journals, and as a scientific reviewer for 10+ scientific journals.

EXPERTISE

Bioinformatics
  • Whole genome sequencing analysis

  • Genetic variant analysis

  • Bulk/Single-cell/Spatial Transcriptomics

  • Epigenomics

  • Proteomics

  • Metabolomics

  • Pipeline and software development

  • ML/AI

  • Biomarker discovery

  • Systems biology

Biostatistics
  • Data mining and analytics

  • Statistical models

  • Clustering algorithms

  • Association analysis (GWAS)

  • Network analysis

  • Functional enrichment

  • Graphical visualization

Population Genomics
  • Epidemiology

  • Personalized genomics

  • Population structure

  • Admixture analysis

  • Genetic diversity

  • Population migration

  • Selection

MY LATEST RESEARCH

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Transcriptomic and clinical heterogeneity of metastatic disease timing within metastatic castration-sensitive prostate cancer.

Ann Oncol. 2023 May 8;34(7):605–614.

© 2017 - 2026 Amol Carl Shetty
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